Carbon monoxide protects rat lung transplants from ischemia-reperfusion injury via a mechanism involving p38 MAPK pathway.

@article{Kohmoto2007CarbonMP,
  title={Carbon monoxide protects rat lung transplants from ischemia-reperfusion injury via a mechanism involving p38 MAPK pathway.},
  author={Junichi Kohmoto and Atsunori Nakao and Donna B Stolz and Takashi Kaizu and Allan Tsung and Atsushi Ikeda and Hiroko Shimizu and Tsuyoshi Takahashi and Koji Tomiyama and Ryujiro Sugimoto and Augustine M. K. Choi and Timothy R Billiar and N Oboru Murase and K. R. Mccurry},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2007},
  volume={7 10},
  pages={
          2279-90
        }
}
Carbon monoxide (CO) provides protection against oxidative stress via anti-inflammatory and cytoprotective actions. In this study, we tested the hypothesis that a low concentration of exogenous (inhaled) CO would protect transplanted lung grafts from cold ischemia-reperfusion injury via a mechanism involving the mitogen-activated protein kinase (MAPK) signaling pathway. Lewis rats underwent orthotopic syngeneic or allogeneic left lung transplantation with 6 h of cold static preservation… CONTINUE READING
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