Carbon monoxide produced by intrasinusoidally located haem-oxygenase-1 regulates the vascular tone in cirrhotic rat liver.


BACKGROUND/OBJECTIVE Carbon monoxide (CO) produced by haem-oxygenase isoforms (HO-1 & HO-2) is involved in the regulation of systemic vascular tone. We aimed to elucidate the vasoregulatory role of CO in the microcirculation in normal and thioacetamide cirrhotic rat livers. METHODS Haem-oxygenase expression was examined by Western blot. Total HO enzymatic… (More)
DOI: 10.1111/j.1478-3231.2008.01857.x

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