Carbon monoxide prevents ventilator-induced lung injury via caveolin-1.

@article{Hoetzel2009CarbonMP,
  title={Carbon monoxide prevents ventilator-induced lung injury via caveolin-1.},
  author={Alexander Hoetzel and Rene Schneider Hansj{\"o}rg Schmidt and Simone Vallbracht and Ulrich Goebel and Tam{\'a}s Dolinay and Hong Pyo Kim and Emeka Ifedigbo and Stefan W. Ryter and Augustine M. K. Choi},
  journal={Critical care medicine},
  year={2009},
  volume={37 5},
  pages={1708-15}
}
OBJECTIVES Carbon monoxide (CO) can confer anti-inflammatory protection in rodent models of ventilator-induced lung injury (VILI). Caveolin-1 exerts a critical role in cellular responses to mechanical stress and has been shown to mediate cytoprotective effects of CO in vitro. We sought to determine the role of caveolin-1 in lung susceptibility to VILI in mice. Furthermore, we assessed the role of caveolin-1 in the tissue-protective effects of CO in the VILI model. DESIGN Prospective… CONTINUE READING
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