Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs.

@article{Mazzola2005CarbonMP,
  title={Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs.},
  author={Silvia Michela Mazzola and Monica Forni and Mariangela Albertini and Maria Laura Bacci and Augusta Zannoni and Fabio Gentilini and Marialuisa Lavitrano and Fritz Heintz Bach and Leo E Otterbein and Maria Giovanna Clement},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 14},
  pages={2045-7}
}
Endotoxic shock, one of the most prominent causes of mortality in intensive care units, is characterized by pulmonary hypertension, systemic hypotension, heart failure, widespread endothelial activation/injury, and clotting culminating in disseminated intravascular coagulation and multi-organ system failure. In the last few years, studies in rodents have shown that administration of low concentrations of carbon monoxide (CO) exerts potent therapeutic effects in a variety of diseases/disorders… CONTINUE READING

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