Carbon monoxide involved in modulating HCO3- secretion in rat duodenum.

@article{Takasuka2011CarbonMI,
  title={Carbon monoxide involved in modulating HCO3- secretion in rat duodenum.},
  author={Hironori Takasuka and Shusaku Hayashi and Masafumi Koyama and Masashi Yasuda and Eitaro Aihara and Kikuko Amagase and Koji Takeuchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={337 1},
  pages={293-300}
}
We examined the effect of the tricarbonyl-dichlororuthenium (II) dimer (CORM-2), a carbon monoxide (CO) donor, on duodenal HCO(3)(-) secretion in rats and investigated whether endogenous CO produced by heme oxygenase (HO) is involved in the regulation of this secretion. Under urethane anesthesia, a duodenal loop was perfused with saline, and HCO(3)(-) secretion was measured at pH 7.0 using a pH stat method. CORM-2, biliverdin, FeCl(2), or ruthenium (III) chloride hydrate (RuCl(3)) was applied… CONTINUE READING