Carbon monoxide intoxication: An updated review

@article{Prockop2007CarbonMI,
  title={Carbon monoxide intoxication: An updated review},
  author={Leon D. Prockop and Rossitza I. Chichkova},
  journal={Journal of the Neurological Sciences},
  year={2007},
  volume={262},
  pages={122-130}
}
Carbon monoxide (CO), a highly toxic gas produced by incomplete combustion of hydrocarbons, is a relatively common cause of human injury. Human toxicity is often overlooked because CO is tasteless and odorless and its clinical symptoms and signs are non specific. The brain and the heart may be severely affected after CO exposure with carboxyhemoglobin (COHb) levels exceeding 20%. Damage occurs because the affinity of hemoglobin for CO is 210 times higher than for O(2). Hypoxic brain damage… 
View on Elsevier
biomechanicsofinjury.com
583 Citations
Highly Influential Citations
22
Background Citations
176
Methods Citations
8
Results Citations
4

583 Citations

Citation Type

Citation Type

Carbon Monoxide Intoxication: Experiences from Hungary
TLDR
Fatal CO intoxication can occur due to plain early signs and symptoms, and hyperbaric oxygen therapy should be considered in severe intoxication, in fetal and children.
The Diagnosis and Treatment of Carbon Monoxide Poisoning.
TLDR
High-quality, prospective, randomized trials that would enable a definitive judgment of the efficacy of HBOT are currently lacking, and there is no general recommendation for HBOT.
Chorea in acute carbon monoxide intoxication
TLDR
A patient with acute consciousness impairment and generalised chorea that had been exposed to toxic levels of CO for a few nights is described, conviction that he presented chorea as part of an acute CO intoxication.
Clinical manifestation, effects, diagnosis, monitoring of carbon monoxide poisoning and toxicity
TLDR
It is identified that carbon monoxide may be quantitated in blood using spectrophotometric methods or chromatographic techniques in order to confirm the diagnosis of poisoning in hospitalized victims or to assist in the forensic investigation of a case of fatal exposure.
The neurotoxicology of carbon monoxide – Historical perspective and review
TLDR
Concepts of how recent developments in the understanding of CO toxicology explain the particular susceptibility of the central nervous system to the effects of CO exposure are illustrated are illustrated.
Carbon Monoxide/Cyanide
Carbon monoxide (CO) poisoning is the leading cause of both accidental and intentional poisoning deaths in the United States. Carbon monoxide produces its toxic effects primarily by reducing the…
Carbon Monoxide Intoxication - Review
CO, binds to the iron atoms in hemoglobin, with an affinity 200-250 times that of oxygen, and impairs oxygen carrying capacity of the blood. Hence, CO toxicity is a situation characterized by…
Chapter 4 Carbon Monoxide Intoxication : Experiences from Hungary Edit Gara
Carbon monoxide (CO) is odorless, colorless, tasteless, and nonirritating gas. Hence, mild CO poisoning often remains unrecognized and appears lethally. Carbon and gas systems, unfavorable…
Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy
TLDR
Although hyperbaric oxygen significantly reduces the permanent neurological and affective effects of CO poisoning, a portion of survivors still have substantial morbidity, and there has been some early success in therapies targeting the downstream inflammatory and oxidative effects ofCO poisoning.
Delayed hyperbaric oxygen treatment after acute carbon monoxide poisoning
TLDR
A 62 year old man suffering from a striking neurologic decline after complete recovery from severe COpoisoning, who recovered after delayed HBO2 treatment, which revealed severe dysfunction in all cognitive domains.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
Carbon monoxide poisoning: systemic manifestations and complications.
  • I. Choi
  • Medicine
    Journal of Korean medical science
  • 2001
TLDR
Severe neurological manifestations may occur days or weeks after acute CO poisoning, and delayed sequelae of CO poisoning are not rare, usually occur in middle or older, and are clinically characterized by symptom triad of mental deterioration, urinary incontinence, and gait disturbance.
Identifying and managing adverse environmental health effects: 6. Carbon monoxide poisoning.
TLDR
The clinical management of carbon monoxide poisoning is outlined, strategies and resources to prevent exposure are provided and a simple tool based on the CH2OPD2 mnemonic is demonstrated that physicians can use to obtain an environmental exposure history.
Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen.
Carbon Monoxide Brain Toxicity: Clinical, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, and Neuropsychological Effects in 9 People
  • L. Prockop
  • Medicine
    Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • 2005
TLDR
It is demonstrated that although MRI and MRS are useful markers of CO‐induced brain damage, they are not always sensitive to resultant intellectual dysfunction.
Analysis of carbon monoxide
  • B. Widdop
  • Chemistry, Medicine
    Annals of clinical biochemistry
  • 2002
TLDR
For the investigation of low-level exposure and the detection of increased haemolysis in neonates, more sensitive methods involving the release of carbon monoxide and its measurement by gas chromatography are required.
Magnetic resonance imaging findings in chronic carbon monoxide intoxication
TLDR
Patients with severe CO intoxication may develop persistent cerebral changes independently of their neuropsychiatric findings in the chronic stage, even if asymptomatic, according to the MRI findings of chronic stage CO intoxication.
Myocardial toxicity from carbon monoxide poisoning.
TLDR
A report was presented of 4 cases of CO poisoning, in one case all were members of the same family found unconscious in their home with an unvented heater, where the infant died with carboxyhemoglobin (COHb) of 55%.
Carbon monoxide poisoning: risk factors for cognitive sequelae and the role of hyperbaric oxygen.
TLDR
HBO(2) oxygen is indicated for patients with acute CO poisoning who are 36 years or older or have exposure intervals greater than or equal to 24 hours, and subgroup analyses support that patients with loss of consciousness or higher carboxyhemoglobin levels warrant HBO(2).
Carbon monoxide poisoning: a five year review at Tan Tock Seng Hospital, Singapore.
  • P. Handa, D. Tai
  • Medicine
    Annals of the Academy of Medicine, Singapore
  • 2005
TLDR
COP is relatively uncommon in Singapore and has a low rate of short- and long-term complications, including parkinsonism after a follow-up of 2 years.
Carboxyhemoglobin measurement by hospitals: implications for the diagnosis of carbon monoxide poisoning.
TLDR
Fewer than one-half of acute care hospitals in a four-state region have the capability to measure COHb levels, which has the potential to significantly impact diagnosis or treatment of patients with acute CO poisoning.
...
1
2
3
4
5
...