Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation.

  title={Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation.},
  author={Shakil Ahmad and Peter William Hewett and Takeshi Fujisawa and Samir Sissaoui and Meng Cai and Geraldine Gueron and Bahjat Al‐Ani and Melissa J. Cudmore and S Faraz Ahmed and Michael K. K. Wong and Barbara Wegiel and Leo E. Otterbein and Libor V{\'i}tek and Wenda Ramma and Keqing Wang and Asif Ahmed},
  journal={Thrombosis and haemostasis},
  volume={113 2},
Carbon monoxide (CO) is a gaseous autacoid known to positively regulate vascular tone; however, its role in angiogenesis is unknown. The aim of this study was to investigate the effect of CO on angiogenesis and vascular endothelial growth factor (VEGF) receptor-2 phosphorylation. Human umbilical vein endothelial cells (HUVECs) were cultured on growth factor-reduced Matrigel and treated with a CO-releasing molecule (CORM-2) or exposed to CO gas (250 ppm). Here, we report the surprising finding… 

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