Carbon monoxide in alveolar air as an index of exposure to cigarette smoke.

@article{Rawbone1976CarbonMI,
  title={Carbon monoxide in alveolar air as an index of exposure to cigarette smoke.},
  author={Roger G. Rawbone and C A Coppin and Abraham Guz},
  journal={Clinical science and molecular medicine},
  year={1976},
  volume={51 5},
  pages={
          495-501
        }
}
1. A rapid method for the analysis of CO in expired air has been developed, which is suitable for use in studies of smoking. 2. The Bohr equation has been used to calculate the mean alveolar CO partial pressure (PA,CO). 3. The values of PA,CO obtained are highly correlated with direct measurements of venous carboxyhaemoglobin (r = 0-96). 4. The method will distinguish between populations of smokers and non-smokers, and can allow the changes of CO in a smoker throughout a 12 h period to be… 
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Evaluation of methods used to estimate inhaled dose of carbon monoxide.

Estimation of carbon monoxide exposure discriminated between non-smokers and smokers as well as measurements of COHb, and should prove a valuable method for validating reported smoking habits of people attending smoking advisory centres and for epidemiological surveys of smoking.

The measurement of exhaled carbon monoxide is influenced by airflow obstruction.

It is shown that the estimation of carboxyhaemoglobin from exhaled carbon monoxide measurements can be inaccurate in patients with severe airflow obstruction, and in these patients, the direct measurement of carboxesyhaeemoglobin seems advisable in clinical practice.

Carboxyhaemoglobin levels and inhaling habits in cigarette smokers.

The data from this study may help to explain some of the anomalous epidemiological results regarding the relationship between self-described inhaling habits and the development of diseases associated with smoking, such as coronary heart disease and lung cancer.

Cigarette Smoke Inhalation

The pattern of cigarette smoke inhalation wss studied in 19 smokers with respiratory inductive plethysmography, a reliable unobtrusive ventilatory monitoring device, finding no means of predicting the relatively small number of habitual smokers likely to develop chronic airflow limitation.

Evaluation of methods to estimate cigarette smoke uptake

Data on smoke generation and nicotine retention in cigarette butts correlated poorly with all other measures of smoke uptake, and there were positive correlations between increases in heart rate and plasma nicotine concentrations and between percentage carboxyhemoglobin and exhaled carbon monoxide.

Comparison of biochemical and questionnaire estimates of tobacco exposure.

Immediate response to cigarette smoke.

Prior administration of salbutamol and ipratropium bromide significantly inhibited the response and this inhibition appeared to be greater in non-smokers, and Sodium cromoglycate inhaled as a dry powder had no effect on the response.

Exhaled CO, a predictor of lung function?

Is smoker/nonsmoker segregation effective in reducing passive inhalation among nonsmokers?

Results indicate that by comparison to a control group, subjects seated in adjacent smoking/ nonsmoking environments were not only exposed to similar ambient levels of CO, but also show similar physical and physiological reactions to their exposure in the form of coordination test scores, expired CO, and blood carboxyhemoglobin.

The Act of Smoking

Evidence is presented which indicates that individual smokers smoke to a constant amount of work, which suggests that the product may have an important role with its pressure drop showing an inverse relationship to puff volume during smoking.

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