Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

  title={Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway},
  author={Leo E Otterbein and Fritz Heintz Bach and Jawed Alam and Miguel P Soares and Hong Tao Lu and Mark Wysk and Roger J Davis and Richard A Flavell and Augustine M. K. Choi},
  journal={Nature Medicine},
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress. The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this cytoprotection. We demonstrate here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects. Both in vivo and in vitro, carbon monoxide at low concentrations differentially and selectively inhibited the expression of lipopolysaccharide-induced pro-inflammatory… CONTINUE READING
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