Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone.

@article{Coceani1997CarbonMF,
  title={Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone.},
  author={Flavio Coceani and Lois B Kelsey and Eric Seidlitz and Gerald S. Marks and Brian E McLaughlin and H. Vreman and David K. Stevenson and Marlene Rabinovitch and Cameron A. Ackerley},
  journal={British journal of pharmacology},
  year={1997},
  volume={120 4},
  pages={599-608}
}
1. We have previously shown that carbon monoxide (CO) potently relaxes the lamb ductus arteriosus and have ascribed this response to inhibition of a cytochrome P450-based mono-oxygenase reaction controlling the formation of endothelin-1 (ET-1). In the present study, we have examined whether CO is formed naturally in the vessel. 2. The CO-forming enzyme, haem oxygenase (HO), was identified in ductal tissue in its constitutive (HO-2) and inducible (HO-1) isoforms by Western immunoblotting and… CONTINUE READING
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