Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells.

@article{Morita1997CarbonMC,
  title={Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells.},
  author={Takashi Morita and S. Alex Mitsialis and Hisashi Koike and Ying Liu and Stella Kourembanas},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 52},
  pages={32804-9}
}
Excess vascular smooth muscle cell (VSMC) proliferation and contractility are key events in the pathophysiology of vascular disorders induced by hypoxia. We have recently reported that carbon monoxide (CO), produced by VSMC under conditions of hypoxia, can be a modulator of cGMP levels in both endothelial and smooth muscle cells. In this respect, some of the physiologic effects of CO in the vasculature parallel those of nitric oxide (NO), a well characterized regulator of vascular tone. We… CONTINUE READING

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