Carbon monoxide as an endogenous vascular modulator.

  title={Carbon monoxide as an endogenous vascular modulator.},
  author={Charles W. Leffler and Helena Parfenova and Jonathan H Jaggar},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={301 1},
Carbon monoxide (CO) is produced by heme oxygenase (HO)-catalyzed heme degradation to CO, iron, and biliverdin. HO has two active isoforms, HO-1 (inducible) and HO-2 (constitutive). HO-2, but not HO-1, is highly expressed in endothelial and smooth muscle cells and in adjacent astrocytes in the brain. HO-1 is expressed basally only in the spleen and liver but can be induced to a varying extent in most tissues. Elevating heme, protein phosphorylation, Ca(2+) influx, and Ca(2+)/calmodulin… CONTINUE READING


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Carbon monoxide activates KCa channels in newborn cerebral arteriole smooth muscle cells by increasing the apparent Ca 2 sensitivity of subunits

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