Carbon monoxide and iron modulate plasmatic coagulation in Alzheimer's disease.

@article{Nielsen2015CarbonMA,
  title={Carbon monoxide and iron modulate plasmatic coagulation in Alzheimer's disease.},
  author={Vance G. Nielsen and Etheresia Pretorius and Janette Bester and Wayne K. Jacobsen and Patrick K Boyle and Joao P Reinhard},
  journal={Current neurovascular research},
  year={2015},
  volume={12 1},
  pages={
          31-9
        }
}
Alzheimer's disease (AD) is a significant source of morbidity and mortality for millions of people worldwide, and multiple potential etiologies have been postulated to contribute to AD. Among these, spontaneous cerebral emboli and increased cerebral and circulating heme oxygenase (Hmox) activity in AD patients are of particular interest, as two of the products of Hmox activity, carbon monoxide (CO) and iron enhance plasmatic coagulation and modify the ultrastructure of thrombi. We hypothesized… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium
TLDR
It is argued that AD can be prevented by limiting the dietary supply of trivalent iron contained in red and processed meat; increasing the intake of chlorophyll-derived magnesium; and consumption of foods rich in polyphenolic substances and certain aliphatic and aromatic unsaturated compounds known to be associated with the lower incidence of AD. Expand
High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease
TLDR
It is argued that high ferritin levels may contribute to an accelerated pathology in AD, and the possibility both of an early diagnosis and some means of treating or slowing down the progress of this disease is suggested. Expand
Iron-enhanced coagulation is attenuated by chelation A thrombelastographic and ultrastructural analysis
  • V. Nielsen, E. Pretorius
  • Chemistry, Medicine
  • Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • 2014
TLDR
Using clinically encountered concentrations of iron created by addition of FeCl3 to human plasma, it is demonstrated that iron-mediated changes in reaction time determined by thrombelastography or changes in thrombus ultrastructure were significantly, but not completely, reversed by iron chelation with deferoxamine. Expand
Iron and carbon monoxide enhance coagulation and attenuate fibrinolysis by different mechanisms
  • V. Nielsen, E. Pretorius
  • Chemistry, Medicine
  • Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • 2014
TLDR
The first evidence that iron and carbon monoxide interact with key coagulation and fibrinolytic processes, resulting in thrombi that begin to form more quickly, grow faster, become stronger, and are more resistant to lysis is presented. Expand
Bariatric patients have plasmatic hypercoagulability and systemic upregulation of heme oxygenase activity
TLDR
Whether morbidly obese patients undergoing bariatric surgery had an increase in endogenous CO and plasmatic hypercoagulability is determined and Hmox-derived CO in the pathogenesis of obesity-related thrombophilia is warranted. Expand
The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation
TLDR
A mechanism is proposed that reconciles these two hypotheses noted above of neurotoxic and the neuroprotective aspects of this important stress responsive system, HO-1/BVR-A. Expand
Heme oxygenase derived carbon monoxide and iron mediated plasmatic hypercoagulability in a patient with calcific mitral valve disease
TLDR
It was determined that the patient’s plasmatic hypercoagulability was in part due to carboxyhemefibrinogen formation and iron-enhancement of coagulation via two thrombelastographic methods. Expand
Metal and complementary molecular bioimaging in Alzheimer's disease
TLDR
Neuroimaging of metals in a variety of intact brain cells and tissues is emerging as an important tool for increasing the authors' understanding of the role of metal dysregulation in AD, and emerging mass spectrometric and molecular imaging techniques provide new techniques to probe the pathobiology of AD. Expand
The link between iron, metabolic syndrome, and Alzheimer’s disease
TLDR
This review sets to cover the current literature regarding OS and iron in MetS and T2DM and the similarities to mechanisms in AD both in human subjects as well as in animal models. Expand
Hemodialysis Patients Have Plasmatic Hypercoagulability and Decreased Fibrinolytic Vulnerability: Role of Carbon Monoxide
TLDR
Carbon monoxide enhanced coagulation and diminished fibrinolytic vulnerability in hemodialysis patients is determined, and future investigation of he modialysis, CO-related thrombophilia is warranted. Expand
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