Carbon monoxide alleviates cadmium-induced oxidative damage by modulating glutathione metabolism in the roots of Medicago sativa.

@article{Han2008CarbonMA,
  title={Carbon monoxide alleviates cadmium-induced oxidative damage by modulating glutathione metabolism in the roots of Medicago sativa.},
  author={Yi Chiew Han and Jing Jun Zhang and Xiaoyue Chen and Zhaozhou Gao and Wei Peng Xuan and Sheng Xu and Xiao Ding and Wenbiao Shen},
  journal={The New phytologist},
  year={2008},
  volume={177 1},
  pages={155-66}
}
Using pharmacological and biochemical approaches, the role of cadmium (Cd)-induced carbon monoxide (CO) release and the relationship between CO and oxidative stress conferred by Cd exposure in the root tissues of alfalfa (Medicago sativa) plants were investigated. Cd treatments showed a dose-dependent enhancement in lipid peroxidation. Both 100 and 200 microm CdCl(2 )treatments caused the increase of CO release, which is consistent with the changes in the activity of the CO synthetic enzyme… CONTINUE READING

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