Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism.

@article{Lim2005CarbonMA,
  title={Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism.},
  author={Inja Lim and Simon J. Gibbons and Gregory L Lyford and Steven M. Miller and Peter R Strege and Michael G. Sarr and Suvro Chatterjee and Joseph H. Szurszewski and Vijay H Shah and Gianrico Farrugia},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2005},
  volume={288 1},
  pages={G7-14}
}
Carbon monoxide (CO) is increasingly recognized as a physiological messenger. CO is produced in the gastrointestinal tract with diverse functions, including regulation of gastrointestinal motility, interacting with nitric oxide (NO) to mediate neurotransmission. The aim of this study was to determine the effect of CO on the human intestinal L-type Ca(2+) channel expressed in HEK cells and in native cells using the patch-clamp technique. Extracellular solution contained 10 mM Ba(2+) as the… CONTINUE READING