Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.

@article{Kim2008CarbonMA,
  title={Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.},
  author={Hoe Suk Kim and Patricia Loughran and Jayashree Rao and Timothy R Billiar and Brian S Zuckerbraun},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 1},
  pages={G146-G152}
}
Heme oxygenase overexpression or exogenous carbon monoxide (CO) protects against hepatocyte apoptosis and fulminant hepatitis. The prevention of hepatocyte apoptosis by CO has been shown to require activation of NF-kappaB. The purpose of these investigations was to determine the mechanism of CO-induced hepatocyte NF-kappaB activation and protection against apoptosis. Primary rat or mouse hepatocytes and Hep3B cells were utilized. CO exposure was performed at 250 parts per million. Main outcome… CONTINUE READING
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Heme Oxygenase: The Elegant Orchestration of Its Products in Medicine

  • L Otterbein, B. Zuckerbraun
  • Hauppauge, New York: Nova Science,
  • 2005
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