Carbon monoxide: mechanisms of action and potential clinical implications.


Small amounts of carbon monoxide (CO) are continuously produced in mammals. The intracellular levels of CO can increase under stressful conditions following the induction of HO-1 (heme oxygnase-1), a ubiquitous enzyme responsible for the catabolism of heme. Unlike nitric oxide, which is a free radical, CO does not contain free electrons but may be involved… (More)
DOI: 10.1016/j.pharmthera.2012.09.007


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