Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications


Carbon monoxide (CO) is a gaseous product generated by heme oxygenase (HO), which oxidatively degrades heme. While the stress-inducible HO-1 has well been recognized as an anti-oxidative defense mechanism under stress conditions, recent studies suggest that cancer cells utilize the reaction for their survival. HO-2, the constitutive isozyme, also plays… (More)
DOI: 10.1007/s00109-012-0875-2


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