Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

@article{Suematsu1995CarbonMA,
  title={Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.},
  author={Makoto Suematsu and Nobuhito Goda and Tsuyoshi Sano and Satoshi Kashiwagi and Tsuyoshi Egawa and Yuichi Shinoda and Yuzuru Ishimura},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 5},
  pages={
          2431-7
        }
}
Heme oxygenase is a heme-oxidizing enzyme which generates biliverdin and carbon monoxide (CO). The present study was designed to elucidate whether CO endogenously produced by this enzyme serves as an active vasorelaxant in the hepatic microcirculation. Microvasculature of the isolated perfused rat liver was visualized by dual-color digital microfluorography to alternately monitor sinusoidal lining and fat-storing Ito cells. In the control liver, the CO flux in the venous effluent ranged at 0.7… Expand
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