Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation.

@article{Wunder2005CarbonMB,
  title={Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation.},
  author={Christian Wunder and Robert W. Brock and Stefan Frantz and Winfried Goettsch and Henning Morawietz and Norbert Roewer and Otto Eichelbroenner},
  journal={Critical care medicine},
  year={2005},
  volume={33 10},
  pages={
          2323-31
        }
}
OBJECTIVE Endothelin-1 and carbon monoxide play a major role in the regulation of liver microcirculation in numerous disease states. During sepsis and endotoxemia, elevated formation of endothelin-1 results in reduced sinusoidal blood flow. However, the role of carbon monoxide and endothelin-1 and its receptors endothelin receptor A and endothelin receptor B in the deranged liver microcirculation during early systemic inflammation remains unclear. DESIGN Prospective, randomized, controlled… CONTINUE READING
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