Carbon ion radiotherapy as a treatment modality for paediatric cancers.

  title={Carbon ion radiotherapy as a treatment modality for paediatric cancers.},
  author={Tatsuya Ohno and Masahiko Okamoto},
  journal={The Lancet. Child \& adolescent health},
  volume={3 6},
  • T. Ohno, M. Okamoto
  • Published 1 April 2019
  • Medicine
  • The Lancet. Child & adolescent health
Safety verification of carbon-ion radiotherapy for patients with cardiac implantable electronic devices (CIEDs).
Although carbon-ion beam therapy can be safely administered to patients with CIEDs, it is advisable to perform the therapy with sufficient preparation and backup devices because of the risks involved.
Physics and biomedical challenges of cancer therapy with accelerated heavy ions
The physical basis and the clinical data with carbon ions and the use of different ions, such as helium and oxygen are reviewed and the challenges in physics and radiobiology to make particle therapy affordable are discussed.
High Relative Biological Effectiveness of 2 MeV Fast Neutrons for Induction of Medulloblastoma in Ptch1+/– Mice with Radiation-specific Deletion on Chromosome 13
Results indicate that the developmental stage at exposure of the tissue influences the RBE of neutrons, which is an important modifier of the effects of radiation, including carcinogenesis, with infants being generally more radiosensitive.
Carbon Ion Therapy: A Modern Review of an Emerging Technology
A comprehensive review of the studies of carbon ion radiotherapy for almost every type of malignancy, including intracranial malignancies, head and neck malignANCs, primary and metastatic lung cancers, tumors of the gastrointestinal tract, prostate and genitourinary cancers, sarcomas, cutaneous malIGNancies, breast cancer, gynecologic malignations, and pediatric cancers is provided.


Patterns of proton therapy use in pediatric cancer management in 2016: An international survey.
Carbon ion radiotherapy for inoperable pediatric osteosarcoma
CIRT was safe and efficacious in the treatment of inoperable pediatric osteosarcoma with improved local control and overall survival compared to conventional treatments.
Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy with a passive beam: Organ doses in prostate cancer treatment.
  • S. Yonai, N. Matsufuji, K. Akahane
  • Medicine, Physics
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2018
Measurement of neutron ambient dose equivalent in passive carbon-ion and proton radiotherapies.
It was found that the neutron ambient dose equivalent in passive particle radiotherapy is equal to or less than that in the photon radiotherapy, which means that not only scanning particle radiotherapies but also passive particles radiotherapy can provide reduced exposure to normal tissues around the target volume without an accompanied increase in total body dose.
Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk
The authors summarized the outcomes of patients with unresectable osteosarcoma of the trunk who received carbon ion radiotherapy (CIRT).
Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base
The current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas and chondrosarcomas.
Charged-particle therapy in cancer: clinical uses and future perspectives
Several randomized trials of charged-particle therapies that are ongoing are reviewed, with results that will enable selective delivery to patients who are most likely to benefit from them and aspects related to radiobiology, including the immune response and hypoxia, which will need to be taken into consideration in future randomized trials to fully exploit the potential of charged particles.