Carbon dioxide mediates duodenal mucosal alkaline secretion in response to luminal acidity in the anesthetized rat.

@article{Holm1998CarbonDM,
  title={Carbon dioxide mediates duodenal mucosal alkaline secretion in response to luminal acidity in the anesthetized rat.},
  author={Mathias Holm and Barbro Johansson and Anders Pettersson and Lars F{\"a}ndriks},
  journal={Gastroenterology},
  year={1998},
  volume={115 3},
  pages={680-5}
}
BACKGROUND & AIMS Acid exposure of the duodenum elicits various functional responses, e.g., an increased mucosal alkaline secretion. Despite low pH in luminal contents, the mucosal secretion of bicarbonate-rich fluid results in pH neutrality at the surface epithelium. It follows that it is probably not luminal pH that triggers the secretory response. The present study was undertaken to investigate if CO2 could serve as an intermediate messenger between luminal acid and the mucosal secretory… CONTINUE READING

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