Carbon dioxide inhalation reduces the function of GABAA receptors in the rat brain.

@article{Sanna1992CarbonDI,
  title={Carbon dioxide inhalation reduces the function of GABAA receptors in the rat brain.},
  author={Enrico Sanna and T. Cuccheddu and Mariangela Serra and A Concas and Giovanni Biggio},
  journal={European journal of pharmacology},
  year={1992},
  volume={216 3},
  pages={457-8}
}
The effect of CO2 inhalation on the function of the GABA(A)-coupled chloride channel was evaluated in rat brain. This treatment decreased the capability of GABA to stimulate 36Cl- uptake and produced a significant increase of [35S]-TBPS ([35S]t-butylbicyclophosphorothionate) binding in the cerebral cortex, cerebellum and hippocampus. These results demonstrate that a brief exposure of rats to CO2 inhalation reduces the function of the GABA(A)-ionophore receptor complex in rat brain.