Carbon catabolite repression in bacteria: many ways to make the most out of nutrients
@article{Grke2008CarbonCR, title={Carbon catabolite repression in bacteria: many ways to make the most out of nutrients}, author={Boris G{\"o}rke and J{\"o}rg St{\"u}lke}, journal={Nature Reviews Microbiology}, year={2008}, volume={6}, pages={613-624} }
Most bacteria can selectively use substrates from a mixture of different carbon sources. The presence of preferred carbon sources prevents the expression, and often also the activity, of catabolic systems that enable the use of secondary substrates. This regulation, called carbon catabolite repression (CCR), can be achieved by different regulatory mechanisms, including transcription activation and repression and control of translation by an RNA-binding protein, in different bacteria. Moreover…
1,284 Citations
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A demand-based catabolite repression mechanism is proposed in C. jejuni, depended on intracellular succinate levels, that inhibits the utilization of other carbon sources, by repressing the expression of a number of central metabolic enzymes.
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The data suggest that the hierarchy in CCR exerted by the different substrates is exclusively determined by the activity of HPrK/P, and the substrates form a hierarchy in their ability to exert repression via the CcpA-mediated CCR pathway.
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- BiologyWorld journal of microbiology & biotechnology
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Evidence is presented for a surprising exception to carbon catabolite inactivation in the fungal pathogen Candida albicans, an organism that makes use of gluconeogenic carbon sources during infection and which lacks consensus ubiquitination sites found in the yeast homologs.
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