Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

  title={Carbon catabolite repression in bacteria: many ways to make the most out of nutrients},
  author={Boris G{\"o}rke and J{\"o}rg St{\"u}lke},
  journal={Nature Reviews Microbiology},
Most bacteria can selectively use substrates from a mixture of different carbon sources. The presence of preferred carbon sources prevents the expression, and often also the activity, of catabolic systems that enable the use of secondary substrates. This regulation, called carbon catabolite repression (CCR), can be achieved by different regulatory mechanisms, including transcription activation and repression and control of translation by an RNA-binding protein, in different bacteria. Moreover… 
Carbon catabolite repression in Pseudomonas : optimizing metabolic versatility and interactions with the environment.
  • F. Rojo
  • Biology
    FEMS microbiology reviews
  • 2010
This review summarizes the regulatory mechanisms responsible for CCR in the bacteria of the genus Pseudomonas, which can live in many different habitats and has implications in the optimization of biotechnological processes such as biotransformations or bioremediation strategies.
Catabolite repression in Campylobacter jejuni correlates with intracellular succinate levels
A demand-based catabolite repression mechanism is proposed in C. jejuni, depended on intracellular succinate levels, that inhibits the utilization of other carbon sources, by repressing the expression of a number of central metabolic enzymes.
Carbon Catabolite Repression in Bacillus subtilis: Quantitative Analysis of Repression Exerted by Different Carbon Sources
The data suggest that the hierarchy in CCR exerted by the different substrates is exclusively determined by the activity of HPrK/P, and the substrates form a hierarchy in their ability to exert repression via the CcpA-mediated CCR pathway.
The role of protein phosphorylation in regulation of carbon catabolite repression in Bacillus subtilis
The repressing potential of various carbon sources besides glucose was analysed and the FBP concentration in vivo was determined, indicating that on most sugars the intracellular FBP level is high enough to achieve theoretically a complete activation of the HPrK/P kinase activity.
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This review examines the mechanisms and examples of primary and secondary metabolites subject to carbon catabolite repression in Streptomyces and describes some of the metabolites and protein factors involved.
Carbon Catabolite Control in Candida albicans: New Wrinkles in Metabolism
Evidence is presented for a surprising exception to carbon catabolite inactivation in the fungal pathogen Candida albicans, an organism that makes use of gluconeogenic carbon sources during infection and which lacks consensus ubiquitination sites found in the yeast homologs.


Carbon catabolite repression in bacteria.
The mechanisms of carbon catabolite repression in bacteria.
Carbon catabolite repression in bacteria: choice of the carbon source and autoregulatory limitation of sugar utilization.
Catabolic/metabolic balance would perhaps better describe the physiological role of this regulatory network than the term catabolite repression, as CCR helps bacteria to adjust sugar utilization to their metabolic capacities.
Global control of sugar metabolism: a Gram-positive solution
This review summarises the current understanding of carbon catabolite regulation in low-GC Gram-positive bacteria with special emphasis on lactic acid bacteria.
CcpA-Dependent Carbon Catabolite Repression in Bacteria
In bacteria in the phylum Proteobacteria that contain HPr kinase and XPr, the latter may be at the center of a complex regulatory network involving both CCR and the Ntr system.
Catabolite Regulation of the pta Gene as Part of Carbon Flow Pathways in Bacillus subtilis
ABSTRACT In Bacillus subtilis, the products of thepta and ackA genes, phosphotransacetylase and acetate kinase, play a crucial role in the production of acetate, one of the most abundant by-products
Catabolite Control Protein A (CcpA) Contributes to Virulence and Regulation of Sugar Metabolism in Streptococcus pneumoniae
Comparing the cell wall fraction of the ccpA and wild-type strains shows that CcpA regulates many proteins in this compartment that are involved in central and intermediary metabolism, a subset of which are required for survival and multiplication in vivo.
Carbon catabolite repression of phenol degradation in Pseudomonas putida is mediated by the inhibition of the activator protein PhlR
It is concluded thatPhlR is the target and that carbon catabolite repression of phenol degradation occurs by interfering with the activating function of PhlR, and it is shown that carbonCatabolites repression is a negative control.