Carbon Monoxide and the brain: time to rethink the dogma.

  title={Carbon Monoxide and the brain: time to rethink the dogma.},
  author={Khalid A. Hanafy and Justin Oh and Leo E Otterbein},
  journal={Current pharmaceutical design},
  volume={19 15},
Carbon Monoxide (CO), long thought to be a simple environmental pollutant is now known to have a critical role in cellular functions ranging from vasodilation to circadian rhythms. In this review, we will begin with a discussion of the enzyme responsible for CO production: heme oxygenase. Because this review will focus on the effects of CO in the brain, we will transition to CO toxicology and determine if this simple diatomic gas has really earned its nefarious reputation. An in depth analysis… CONTINUE READING