Carbon Monoxide Cardiotoxicity

@article{Gandini2001CarbonMC,
  title={Carbon Monoxide Cardiotoxicity},
  author={Cristiano Gandini and Anna Federica Castoldi and Stefano Massimo Candura and Carlo Alessandro Locatelli and Raffaella Butera and S. G. Priori and Luigi Manzo},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2001},
  volume={39},
  pages={35 - 44}
}
Cardiac dysfunction including arrhythmias and myocardial ischemia have often been reported in carbon monoxide poisoning; scattered punctiform hemorrhages throughout the heart have been documented in autopsy samples. An appropriate diagnostic approach is crucial to assess carbon monoxide cardiac damage. This evaluation may be confounded by several factors, including the absence of overt symptoms and of specific ischemic changes in the electrocardiogram. In experimental studies, laboratory… 
Pathophysiology, clinics, diagnosis and treatment of heart involvement in carbon monoxide poisoning.
TLDR
No specific treatment other than oxygen delivery can be advocated for cardiac toxicity at present, and 100% oxygen therapy should be continued until the patient is asymptomatic and carboxyhemoglobin levels decrease below 5-10%.
Acute cardiac effects of carbon monoxide poisoning in children
TLDR
Myocardial injury may exist in children with CO poisoning without abnormal ECG findings, and Glasgow Coma Scale score ≤14 and hypotension were associate factors with myocardIAL injury.
Myocardial Infarction in a Young Patient After Acute Exposure to Carbon Monoxide
TLDR
A young person who did not have known coronary atherosclerotic disease and had AMI due to exposure to CO is presented with the aim of drawing attention to the fact that CO poisoning which occurs commonly throughout the world may lead to AMI.
Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation.
TLDR
Findings suggest that CO deteriorates heart oxygen supply to utilization and potentially may induce myocardial hypoxia through mechanisms that include increased oxygen demand due to increased contractility, reduced coronary blood flow reserve, and cardiomyocyte respiration inhibition.
QT dispersion in carbon monoxide poisoning.
TLDR
Emergency physicians should measure QT dispersion in CO intoxicated patients in order to predict the electrical instability in myocardium and future adverse events.
Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current.
TLDR
The data indicate that the proarrhythmic effects of CO arise from activation of NO synthase, leading to NO-mediated nitrosylation of Na(V)1.5 and to induction of the late Na(+) current, and show that the antianginal drug ranolazine can abolish CO-induced early after-depolarizations, highlighting a novel approach to the treatment of CO- induced arrhythmias.
Management of carbon monoxide poisoning-induced cardiac failure and multiorgan dysfunction with combined respiratory and circulatory extracorporeal membrane oxygenation
TLDR
The experience with a case is presented that it is the first case to be published for a patient with acute CO poisoning received both circulatory and respiratory support (hybrid venoarterial-venous ECMO).
A Case of Acute Carbon Monoxide Poisoning Resulting in an ST Elevation Myocardial Infarction
TLDR
A rare case of STEMI complicated by increased thrombogenicity secondary to acute CO poisoning and complete revascularization after antithrombotic treatment is reported.
Ventricular Arrhythmias in Patients with Acute Carbon Monoxide Poisoning are Associated with QT Dispersion
  • 2018
Background: Carbon monoxide (CO) poisoning has a direct myocardial toxicity and arrhythmogenic potential. QT dispersion (QTd), calculated from 12 lead ECG, is an index of heterogeneity of ventricular
Transient left ventricular systolic dysfunction associated with carbon monoxide toxicity.
TLDR
A case with transient LV systolic dysfunction caused by intentional exposure to CO is presented and the patient recovered completely without any complication.
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