Carbon Monoxide Cardiotoxicity

@article{Gandini2001CarbonMC,
  title={Carbon Monoxide Cardiotoxicity},
  author={Cristiano Gandini and Anna Federica Castoldi and Stefano Massimo Candura and Carlo Alessandro Locatelli and Raffaella Butera and S. G. Priori and Luigi Manzo},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2001},
  volume={39},
  pages={35 - 44}
}
Cardiac dysfunction including arrhythmias and myocardial ischemia have often been reported in carbon monoxide poisoning; scattered punctiform hemorrhages throughout the heart have been documented in autopsy samples. An appropriate diagnostic approach is crucial to assess carbon monoxide cardiac damage. This evaluation may be confounded by several factors, including the absence of overt symptoms and of specific ischemic changes in the electrocardiogram. In experimental studies, laboratory… 
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Pathophysiology, clinics, diagnosis and treatment of heart involvement in carbon monoxide poisoning.
TLDR
No specific treatment other than oxygen delivery can be advocated for cardiac toxicity at present, and 100% oxygen therapy should be continued until the patient is asymptomatic and carboxyhemoglobin levels decrease below 5-10%.
Acute cardiac effects of carbon monoxide poisoning in children
TLDR
Myocardial injury may exist in children with CO poisoning without abnormal ECG findings, and Glasgow Coma Scale score ≤14 and hypotension were associate factors with myocardIAL injury.
Myocardial Infarction in a Young Patient After Acute Exposure to Carbon Monoxide
TLDR
A young person who did not have known coronary atherosclerotic disease and had AMI due to exposure to CO is presented with the aim of drawing attention to the fact that CO poisoning which occurs commonly throughout the world may lead to AMI.
Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation.
TLDR
Findings suggest that CO deteriorates heart oxygen supply to utilization and potentially may induce myocardial hypoxia through mechanisms that include increased oxygen demand due to increased contractility, reduced coronary blood flow reserve, and cardiomyocyte respiration inhibition.
QT dispersion in carbon monoxide poisoning.
TLDR
Emergency physicians should measure QT dispersion in CO intoxicated patients in order to predict the electrical instability in myocardium and future adverse events.
Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current.
TLDR
The data indicate that the proarrhythmic effects of CO arise from activation of NO synthase, leading to NO-mediated nitrosylation of Na(V)1.5 and to induction of the late Na(+) current, and show that the antianginal drug ranolazine can abolish CO-induced early after-depolarizations, highlighting a novel approach to the treatment of CO- induced arrhythmias.
Management of carbon monoxide poisoning-induced cardiac failure and multiorgan dysfunction with combined respiratory and circulatory extracorporeal membrane oxygenation
TLDR
The experience with a case is presented that it is the first case to be published for a patient with acute CO poisoning received both circulatory and respiratory support (hybrid venoarterial-venous ECMO).
A Case of Acute Carbon Monoxide Poisoning Resulting in an ST Elevation Myocardial Infarction
TLDR
A rare case of STEMI complicated by increased thrombogenicity secondary to acute CO poisoning and complete revascularization after antithrombotic treatment is reported.
Ventricular Arrhythmias in Patients with Acute Carbon Monoxide Poisoning are Associated with QT Dispersion
  • 2018
Background: Carbon monoxide (CO) poisoning has a direct myocardial toxicity and arrhythmogenic potential. QT dispersion (QTd), calculated from 12 lead ECG, is an index of heterogeneity of ventricular…
Transient left ventricular systolic dysfunction associated with carbon monoxide toxicity.
TLDR
A case with transient LV systolic dysfunction caused by intentional exposure to CO is presented and the patient recovered completely without any complication.
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References

SHOWING 1-10 OF 126 REFERENCES
Carbon monoxide and lethal arrhythmias in conscious dogs with a healed myocardial infarction.
TLDR
It is demonstrated that brief exposure to CO profoundly alters the reflex HR response to exercise and to acute myocardial ischemia and does not enhance the occurrence of malignant arrhythmias in conscious dogs with a healedMyocardial infarction.
Circulatory failure in acute carbon monoxide poisoning.
TLDR
It was concluded that myocardial damage is more frequent in the course of carbon monoxide poisoning than is commonly supposed and in persons who survive the poisoning, the damage may be permanent, leading to invalidism.
Effects of carbon monoxide inhalation on ventricular fibrillation.
TLDR
The voltage required to induce fibrillation was highest for normal, air-breathing animals and lowest for infarcted animals inhaling carbon monoxide, and when the two were combined, the effects were additive.
[Electrocardiographic changes in acute carbon monoxide poisoning].
TLDR
It is concluded that there is no correlation between HbCO levels and electrocardiographic alterations (that were in fact more frequent in the slight poisoning cases).
Echocardiographic findings after acute carbon monoxide poisoning.
TLDR
Though the mitral valve prolapse may have been present before the poisoning, the reported high incidence of papillary muscle lesions in fatal cases suggests a possible relation of the prolapse to the effects of the carbon monoxide poisoning.
Transmural myocardial infarction after exposure to carbon monoxide in coronary-artery disease. Report of a case.
TLDR
This poster explains how carbon monoxide poisoning leads to tissue hypoxia primarily by binding to hemoglobin to form carboxyhemoglobin, which cannot deliver oxygen to the tissues.
Effects of carbon monoxide exposure in patients with documented cardiac arrhythmias.
TLDR
In patients with frequent ventricular ectopic activity, exposure to carbon monoxide producing either 3% or 5% COHb does not increase arrhythmia frequency of single or multiple beats during rest or exercise.
Arrhythmogenic effects of carbon monoxide in experimental acute myocardial ischemia: lack of slowed conduction and ventricular tachycardia.
TLDR
CO may not be arrhythmogenic during early minutes of acute myocardial ischemia, and there was no significant difference between CO and no-CO LAD occlusions in incidence of spontaneous ventricular tachycardia.
Direct effects of carbon monoxide on cardiac function
TLDR
The results showed that the cardiac effects of CO and nitrogen were significantly different as regards changes in arterial pressure, pulse pressure, heart rate, and the product of heart rate and systolic arterial Pressure in spite of the same oxygen tension in the inhaled gases.
[Silent myocardial infarction caused by acute carbon monoxide poisoning].
TLDR
A 63 year-old man who suffered an acute myocardial infarction after carbon monoxide exposure was evaluated in the Emergency Room and did not experience any chest pain, and the electrocardiogram showed non-specific T wave abnormalities in inferolateral leads.
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