Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

  title={Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications},
  author={Lingyun Wu and Rui Wang},
  journal={Pharmacological Reviews},
  pages={585 - 630}
Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, whereas the biological function of the third HO isoform, HO-3, is still unclear. The tissue type-specific… 

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