Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription.

@article{Ishii2004CarbohydrateRE,
  title={Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription.},
  author={Seiji Ishii and Katsumi Iizuka and Bonnie C. Miller and K. M. Uyeda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 44},
  pages={15597-602}
}
Carbohydrate response element (ChRE)-binding protein (ChREBP) is a recently discovered transcription factor that is activated in response to high glucose concentrations in liver independently of insulin. ChREBP was first identified by its ability to bind the ChRE of the liver pyruvate kinase (LPK) gene. We recently reported that the increase in expression of multiple liver lipogenic enzyme mRNAs elicited by feeding a high-carbohydrate diet as well as that of LPK mRNA is markedly reduced in mice… CONTINUE READING
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