Carbohydrate removal fails to eliminate the heterogeneity of human prostatic acid phosphatase.

@article{Morris1989CarbohydrateRF,
  title={Carbohydrate removal fails to eliminate the heterogeneity of human prostatic acid phosphatase.},
  author={Morris Morris and Abdul Waheed and John M. Risley and Robert L Van Etten},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1989},
  volume={182 1},
  pages={9-20}
}
Human prostatic acid phosphatase is known to display considerable charge heterogeneity upon isoelectric focusing. The structural basis of this heterogeneity is not known, although it has been widely attributed to variations in the nature of the carbohydrate chains or to substituents on the carbohydrate chains of the glycoprotein. In this study, the role of the carbohydrate chains in the charge heterogeneity of the protein was examined. First, sialic acid residues were removed by treatment of… CONTINUE READING