Carbohydrate mimics promote functional recovery after peripheral nerve repair.

@article{Simova2006CarbohydrateMP,
  title={Carbohydrate mimics promote functional recovery after peripheral nerve repair.},
  author={Olga Simova and Andrey Irintchev and Ali Mehanna and Jiankun Liu and Marcel Dihn{\'e} and Dirk B{\"a}chle and Norbert Sewald and Gabriele Loers and Melitta Schachner},
  journal={Annals of neurology},
  year={2006},
  volume={60 4},
  pages={
          430-7
        }
}
OBJECTIVE The outcome of peripheral nerve repair is often unsatisfactory, and efficient therapies are not available. We tested the therapeutic potential of functional mimics of the human natural killer cell glycan (3-sulfoglucuronyl beta1-3 galactoside) (HNK-1) epitope, a carbohydrate indicated to favor specificity of motor reinnervation in mice. METHODS We applied a linear HNK-1 mimic peptide, scrambled peptide, or vehicle substances in polyethylene cuffs used to reconstruct the severed… CONTINUE READING
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