Carbohydrate metabolism in perfused livers of adrenalectomized and steroid-replaced rats.

@article{Exton1976CarbohydrateMI,
  title={Carbohydrate metabolism in perfused livers of adrenalectomized and steroid-replaced rats.},
  author={John H. Exton and Thomas B. Miller and S M Harper and C. R. Park},
  journal={The American journal of physiology},
  year={1976},
  volume={230 1},
  pages={163-70}
}
In livers from fasted rats perfused with bicarbonate buffer containing bovine albumin and erythrocytes, adrenalectomy decreased glycogen levels and glucose production, impaired the incorporation of 14C from [14C]lactate into glucose or glycogen, and decreased the activity of the active (I) form of glycogen synthase. Cortisol treatment restored gluconeogenesis after 1 h and glycogen synthesis after 2 h. Adrenalectomy did not alter the production of glucose or lactate or the levels of… CONTINUE READING

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