Carbohydrate metabolism and concentration profiles of solutes in the canine lumbar intervertebral disc.

@article{Holm1982CarbohydrateMA,
  title={Carbohydrate metabolism and concentration profiles of solutes in the canine lumbar intervertebral disc.},
  author={Sten H Holm and Gunnar Selstam and Alf Nachemson},
  journal={Acta physiologica Scandinavica},
  year={1982},
  volume={115 1},
  pages={147-56}
}
Utilization of glucose and oxygen by the cells as well as concentration profiles of solutes were studied in the canine intervertebral disc. Cell metabolism in this avascular tissue, being predominantly anaerobic, was found to be dependent on oxygen tension (this being especially pronounced in the region of 0.13-0.4 kPa (1-3 mmHg). A high production rate of lactic acid was found in the nucleus pulposus, whereas towards the periphery of the annulus fibrosus this rate gradually decreased. In the… CONTINUE READING