Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol.

  title={Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol.},
  author={J O Jeppsson and Hanna Kristensson and Caterina Fimiani},
  journal={Clinical chemistry},
  volume={39 10},
We developed a new fully automated ion-exchange chromatographic method for quantitating carbohydrate-deficient transferrin (CDT) on a Mono Q column. Quantitation relies on the selective absorbance of the iron-transferrin complex at 460 nm. Transferrin isoforms deficient in sialic acid, with pIs 5.7 and 5.9, can easily be separated and quantitated as a percentage of the total transferrin. This method has been applied to samples from teetotalers, occasional drinkers, patients with recent heavy… CONTINUE READING
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