Blood Groups in Infection and Host Susceptibility.
- Laura Cooling
- Clinical microbiology reviews
Blood group antigens of the H, ABO, Lewis, and historical “P” blood groups are defined by small carbohydrate epitopes expressed as posttranslational modifications on glycoproteins, mucins, and glycolipids. Their synthesis is complex and dependent on several distinct glycosyltransferases and interrelated biosynthetic pathways. In many cases, carbohydrate antigens share features of more than one blood group (e.g., ABO and Lewis).