Carbohydrate binding specificities and crystal structure of the cholera toxin-like B-subunit from Citrobacter freundii.

Abstract

Enterotoxigenic Escherichia coli and Vibrio cholerae are well known causative agents of severe diarrheal diseases. Both pathogens produce AB(5) toxins, with one enzymatically active A-subunit and a pentamer of receptor-binding B-subunits. The primary receptor for both B-subunits is the GM1 ganglioside (Galbeta3GalNAcbeta4(NeuAcalpha3)Galbeta4GlcbetaCer… (More)
DOI: 10.1016/j.biochi.2010.02.010

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