Carbohydrate-based cancer vaccines: target cancer with sugar bullets

@article{Liu2012CarbohydratebasedCV,
  title={Carbohydrate-based cancer vaccines: target cancer with sugar bullets},
  author={Chang-Cheng Liu and Xin-Shan Ye},
  journal={Glycoconjugate Journal},
  year={2012},
  volume={29},
  pages={259-271}
}
With the booming development of glycobiology and glycochemistry, more and more structures of tumor-associated carbohydrate antigens (TACAs) are identified. Their broad expression and high specificity in cancer make them important targets to develop cancer vaccines or immunotherapies. However, most of the TACAs are T cell-independent antigens, they cannot elicit a powerful enough immune response to prevent or treat cancer. Immunotolerance and immunosuppression are more easily induced due to… CONTINUE READING
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