Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells

@inproceedings{Noordeen2010CarbohydrateResponsiveEP,
  title={Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells},
  author={Nafeesa Alibhai Noordeen and Tarnjit K. Khera and Gao Sun and E. Rebecca Longbottom and Timothy J. Pullen and Gabriela Da Silva Xavier and Guy A Rutter and Isabelle Leclerc},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Carbohydrate-responsive element-binding protein (ChREBP) is a transcription factor that has been shown to regulate carbohydrate metabolism in the liver and pancreatic beta-cells in response to elevated glucose concentrations. Because few genes have been identified so far as bona fide ChREBP-target genes, we have performed a genome-wide analysis of the ChREBP transcriptome in pancreatic beta-cells. RESEARCH DESIGN AND METHODS Chromatin immunoprecipitation and high-density… CONTINUE READING

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