Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

@inproceedings{CastilloAcosta2016CarbohydrateBindingNP,
  title={Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models},
  author={V{\'i}ctor M. Castillo-Acosta and Luis Miguel Ruiz P{\'e}rez and Juan Etxebarria and Niels-Christian Reichardt and Miguel Navarro and Yasuhiro Igarashi and Sandra Liekens and Jan Balzarini and Dolores Gonz{\'a}lez-Pacanowska},
  booktitle={PLoS pathogens},
  year={2016}
}
Current treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety profiles. Here, we report a new approach to address treatment of this disease based on the use of compounds that bind to parasite surface glycans leading to rapid killing of trypanosomes. Pradimicin and its derivatives are non-peptidic carbohydrate-binding agents that adhere to the carbohydrate moiety of the parasite surface glycoproteins… CONTINUE READING

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