Carbogen and nicotinamide in locally advanced bladder cancer: early results of a phase-III randomized trial.

@article{Hoskin2009CarbogenAN,
  title={Carbogen and nicotinamide in locally advanced bladder cancer: early results of a phase-III randomized trial.},
  author={Peter J. Hoskin and Ana Mar{\'i}a Rojas and Michele I Saunders and S\oren M\oller Bentzen and Kenji Motohashi},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2009},
  volume={91 1},
  pages={120-5}
}
PURPOSE Phase II studies in laryngeal and bladder carcinoma of accelerated radiotherapy with carbogen and nicotinamide (RT+CON) suggested a therapeutic advantage. Therefore, a randomized phase-III trial of RT+CON in locally advanced bladder carcinoma compared to radiotherapy (RT) alone was undertaken. METHODS One hundred and sixty-five patients with muscle-invasive transitional cell bladder carcinoma were randomized to RT alone and 168 to RT+CON. This paper reports on compliance and toxicity… CONTINUE READING
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