Carbocyclic inosine as a potent anti-leishmanial agent: the metabolism and selective cytotoxic effects of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani.

@article{Hiraoka1986CarbocyclicIA,
  title={Carbocyclic inosine as a potent anti-leishmanial agent: the metabolism and selective cytotoxic effects of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani.},
  author={Osamu Hiraoka and Hiroyasu Satake and Shin Iguchi and Akira Minamishinkawa-K Matsuda and Tohru Ueda and Yusuke Wataya},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={134 3},
  pages={
          1114-21
        }
}

Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies.

  • J. Berman
  • Biology, Medicine
    Reviews of infectious diseases
  • 1988
TLDR
Preliminary clinical studies suggest that the purines and the sterol inhibitors may have clinical utility as oral agents against cutaneous leishmaniasis.

The in vitro effects of azithromycin and clarithromycin on promastigotes and amastigotes of Leishmania tropica.

TLDR
In vivo studies should be planned to detect intracellular concentrations of these drugs for the effective route and dosage, and Clarithromycin was found to be more effective than azithromycycin at lower concentrations on promastigotes and amastigote.

3′-Deoxy-3′-fluoroinosine as a potent antileishmanial agent

TLDR
3′-FI (50 mg/kg, given i.v.) showed a cytotoxic effect against the amastigotes of L. donovani in mice and was less toxic toward mouse mammary-tumor FM3A cells, a model host.

A review of natural products with antileishmanial activity.

THERAPEUTIC EFFECT OF INOSINE ANALOGS IN MICE INFECTED WITH LEISHMANIA DONO-VANI OR TR YPANOSOMA GAMBIENSE

L.donovani promastigote 2S-15M株を感染させたBALB/cマウスに対し, 3'-deoxy-inosineは100mg/kg, 1~2回おき5回, 静脈内投与で約63%の治療効果, c-c-inosineは100mg/kg, 1~2日おき5回静脈内投与で約92%の治療効果が見られた。しかし,

Nucleosides and Nucleotides

TLDR
The naturally occurring nucleoside/nucleotide antibiotics, which have been isolated from bacteria, fungi, blue-green algae, and marine sponges, have proven to be useful biochemical probes in eucaryotic, procARYotic, viral, fungal, and plant systems.

References

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    Biochemical and biophysical research communications
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Inhibition of utilization of hypoxanthine and guanine in cells treated with the carbocyclic analog of adenosine. Phosphates of carbocyclic nucleoside analogs as inhibitors of hypoxanthine (guanine) phosphoribosyltransferase.

TLDR
The 5'-phosphates of the carbocyclic analogs of inosine and guanosine were synthesized and found to be effective inhibitors of the phosphoribosyltransferase.

Naturally occurring nucleoside and nucleotide antibiotics.

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Parasite enzymes as potential targets for antiparasitic chemotherapy.

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The conditions for luxuriant axenic cultivation of the trypanosomid flagellate Crithidia fasciculata in chemically-defined media were determined and qualitative and quantitative studies on the nutritional requirements of the organism were carried out.

Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate

TLDR
The selection method described here should be useful for isolating large numbers of thymidylate synthase-negative mutants from various mammalian cell lines.