Carbetocin versus oxytocin for the prevention of postpartum hemorrhage: A meta-analysis of randomized controlled trials in cesarean deliveries.

@article{Voon2018CarbetocinVO,
  title={Carbetocin versus oxytocin for the prevention of postpartum hemorrhage: A meta-analysis of randomized controlled trials in cesarean deliveries.},
  author={Hian Yan Voon and Haris Njoo Suharjono and Asrul Akmal Shafie and Mohamad Adam Bujang},
  journal={Taiwanese journal of obstetrics \& gynecology},
  year={2018},
  volume={57 3},
  pages={
          332-339
        }
}
OBJECTIVE Postpartum hemorrhage remains the leading cause of maternal mortality in developing countries and a significant proportion of these cases are attributable to uterine atony. In contrast to the advances made in the treatment of postpartum hemorrhage, there has been few novel prophylactic agents. This study was undertaken to analyze the effectiveness of carbetocin compared to oxytocin for the prevention of postpartum hemorrhage, in the context of cesarean deliveries. MATERIALS AND… Expand
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TLDR
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There was no statistically significant difference in terms of the need for therapeutic uterotonic agents, but the risk of adverse effects such as nausea and vomiting were significantly lower in the carbetocin group: nausea (RR 0.24; 95% CI 0.15 to 0.40; four trials, 1030 women); vomiting ( RR 0.21; 95%) and a lower mean blood loss in women who received carBetocin compared to syntometrine (mean difference (MD). Expand
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TLDR
Oxytocin and carbetocin have similar requirements for additional uterotonics, estimated blood loss, haemoglobin drop and blood transfusions, and this study found no benefits in using carBetocin over oxytocin. Expand
Double-blind, randomized comparison of the effect of carbetocin and oxytocin on intraoperative blood loss and uterine tone of patients undergoing cesarean section.
TLDR
A single 100 micrograms intravenous injection of carbetocin is as effective and more reliable than a standard continuous infusion of oxytocin in maintaining adequate uterine tone and preventing excessive intraoperative blood loss during cesarean section after delivery of the placenta. Expand
Room temperature stable carbetocin for the prevention of postpartum haemorrhage during the third stage of labour in women delivering vaginally: study protocol for a randomized controlled trial
TLDR
A randomized, double-blind non-inferiority trial comparing a newly developed room temperature stable formulation of carbetocin to the standard intervention (oxytocin) for the prevention of PPH after vaginal birth and could have a substantial impact on the Prevention of postpartum haemorrhage and maternal survival worldwide. Expand
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