Carbenoxolone modifies spontaneous inhibitory and excitatory synaptic transmission in rat somatosensory cortex.

Abstract

Gap junction (GJ) coupling between neocortical GABAergic interneurons plays a critical role in the synchronization of activity in cortical networks in physiological and pathophysiological states, e.g., seizures. Past studies have shown that GJ blockers exert anticonvulsant actions in both in vivo and in vitro models of epilepsy. However, the precise… (More)

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