Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43.

Abstract

Ca(2+)-induced permeability transition pore (mPTP) opening in isolated rat brain mitochondria is promoted through targeting of connexin43. After a threshold Ca(2+) load, mitochondrial membrane potential drops and efflux of accumulated Ca(2+) from the mitochondrial matrix occurs, indicating the mPTP opening. Specific antibodies were used to assess the role… (More)
DOI: 10.1016/j.abb.2014.06.027

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Cite this paper

@article{Azarashvili2014CarbenoxoloneIP, title={Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43.}, author={Tamara S Azarashvili and Yulia Baburina and Dmitry Grachev and O. V. Krestinina and Vassilios Papadopoulos and John J. Lemasters and Irina V Odinokova and Georg Reiser}, journal={Archives of biochemistry and biophysics}, year={2014}, volume={558}, pages={87-94} }