Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.

@article{Rouach2003CarbenoxoloneBO,
  title={Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.},
  author={Nathalie Rouach and Menahem Segal and Annette Koulakoff and Christian Giaume and E. Avignone},
  journal={The Journal of physiology},
  year={2003},
  volume={553 Pt 3},
  pages={729-45}
}
Spontaneous activity in the central nervous system is strongly suppressed by blockers of gap junctions (GJs), suggesting that GJs contribute to network activity. However, the lack of selective GJ blockers prohibits the determination of their site of action, i.e. neuronal versus glial. Astrocytes are strongly coupled through GJs and have recently been shown… CONTINUE READING