Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells.

@article{Heo2007CarbenoxoloneAT,
  title={Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells.},
  author={Ho Jin Heo and Cheolsu Kim and Hyun Jae Lee and Young Sik Kim and Sam Sik Kang and Un Kyo Seo and Yun Hee Kim and Yang Chun Park and Jeong Ho Seok and Choong Jae Lee},
  journal={Phytotherapy research : PTR},
  year={2007},
  volume={21 5},
  pages={462-5}
}
This study investigated whether carbenoxolone, oleanolic acid and ursolic acid affect ATP-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using (3)H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on (3)H-mucin secretion. The possible cytotoxicity of each agent was investigated with a lactate dehydrogenase… CONTINUE READING

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