Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice.

Abstract

Glucocorticoid (GC) excess promotes adipose tissue accumulation, and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in the local amplification of GC. Therefore, in this study, we investigated the effects of carbenoxolone (CBX), an 11β-HSD1 inhibitor, on morphological changes in visceral fat, and the expression of genes involved… (More)
DOI: 10.1055/s-0031-1297990

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@article{Sano2012CarbenoxoloneAT, title={Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice.}, author={Shinichiro Sano and Yusuke Nakagawa and Rie Shigetomi Yamaguchi and Yuko Fujisawa and Eiichiro Satake and Eiichiro Nagata and Takeshi Nakanishi and Y-J Liu and Takehiko Ohzeki}, journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme}, year={2012}, volume={44 1}, pages={15-20} }