Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship.

Abstract

The intestinal absorption of alpha-esters of carbenicillin disodium, carbenicillin phenyl sodium, and carbenicillin indanyl sodium was investigated using the in situ rat intestinal recirculating method. In the in situ intestinal lumen at pH 7, two prodrugs were rapidly converted to poorly absorbable carbenicillin, possibly by the action of intestinal… (More)

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@article{Tsuji1982CarbenicillinPK, title={Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship.}, author={Akira Tsuji and Etsuko Miyamoto and Tetsuya Terasaki and Toshiko Yamana}, journal={Journal of pharmaceutical sciences}, year={1982}, volume={71 4}, pages={403-6} }