Carbazomycins C, D, E and F, minor components of the carbazomycin complex.

  title={Carbazomycins C, D, E and F, minor components of the carbazomycin complex.},
  author={T. Naid and T. Kitahara and M. Kaneda and S. Nakamura},
  journal={The Journal of antibiotics},
  volume={40 2},
Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were elucidated as 4-hydroxy-3,6-dimethoxy-1,2-dimethylcarbazole and 3,4,6-trimethoxy-12-dimethylcarbazole, respectively, by spectroscopic and chemical means. The other components, V and VI, were found to… Expand
40 Citations
Carbazomycins G and H, novel carbazomycin-congeners containing a quinol moiety.
Carbazomycins G (I) and H (II), new congeners of the carbazomycin complex, have been isolated from the culture broth of Streptoverticillium ehimense. They have proved to contain a unique quinolExpand
Biosynthesis of carbazomycin B. II. Origin of the whole carbon skeleton.
The carbazomycins were isolated from Streptoverticillium ehimense H 1051 MY10 as the first antibiotics containing a carbazole nucleus and they mainly inhibit the growth of phytopathogenic fungi3'40.Expand
Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924
Abstract Two new carbazomycin dimers ( 6 and 7 ) and 3-hydroxy-1,2-dimethyl-2,3-dihydro-1 H -carbazol-4-one ( 9 ) together with six known compounds, carbazomycins A–D, cyclomarin C, and pimprinineExpand
Total Synthesis of Carbazomycin G
A concise total synthesis of carbazomycin G has been completed in five steps. Cerium(IV) ammonium nitrate (CAN)–SiO2-mediated oxidation of 2-methyl-2,3,4,9-tetrahydro-1H- carbazol-1-one afforded aExpand
3-Methoxy-2-methyl-carbazole-1,4-quinone, carbazomycins D and F from Streptomyces sp. CMU-JT005.
The isolation and structure elucidation of the compounds are described together with the characterization of the Streptomyces strain CMU-JT005 and 3-Methoxy-2-methyl-carbazole-1,4-quinone is reported here for the first time from nature. Expand
Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
The antibacterial activity of Murrayaquinone A and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione, a synthetic carbazoloquinone obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive and Gram-negative bacteria. Expand
Carbazole alkaloids. III.
Major developments in the chemistry of carbazoles until 1960 arose mainly as a result of their use in the dye stuff and polymer industries although carbazole itself (1) was discovered in coal tar inExpand
Synthesis of carbazoles related to carbazomycin, hyellazole and ellipticine.
Abstract Two synthetic routes to 1,2-disubstituted carbazoles are described. The first involves condensation of 2-alkyl-substituted indoles with 2,3-unsaturated ketones in the presence of Pd/C andExpand
New approach to 3-oxygenated carbazoles. Synthesis of hyellazole and 4-deoxycarbazomycin B
3-Oxygenated carbazoles are prepared in 4 steps from 1 -acetyl-2-methoxy-1,2-dihydroindol-3-one 6 by Wittig reaction with phosphonium ylides 10 to afford the 3-alkylindoles 11, followed by silylationExpand
Chapter 4 Chemistry and Biology of Carbazole Alkaloids
Publisher Summary This chapter explores that carbazole has been discovered from coal tar. The first carbazole from a biological source, the alkaloid murrayanine was isolated from Murraya koenigiiExpand


New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis.
The carbazomycin-producing microorganism, strain H 1051-MY 10, was determined to a strain of Streptoverticillium ehimense and neither of the labeled carbons, [1-14C]tryptophan nor [2,3-13C]propionic acid, was detected in the antibiotic, and a progenitor of the C-2 and C-11 moiety of the antibiotic has not been determined. Expand
New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties.
An unidentified Streptomyces, designated as Strain H 1051-MY 10, was proved to produce viomycin and two new antibiotics, which inhibited the growth of phytophathogenic fungi and further showed weak antibacterial and antiyeast activities. Expand
Xanthonolignoids from Kielmeyera and Caraipa species—13C NMR spectroscopy of xanthones
Abstract Kielcorin and the cadensins A and B , isolated respectively from Kielmeyera coriacea and Caraipa densiflora (Guttiferae), were shown to be xanthonolignoids. The structure of (5S,6S)-6(orExpand
Carbon-13 nuclear magnetic resonance for organic chemists
Previously [i, 2] we have studied 2-chloro-2-oxoas well as 2-chloro-2-thio-l,3,2dioxaphoSphorinanes. It was of interest to ascertain the effect of further substitution of the heteroatom X of the P=XExpand
13C-NMR. Spectroscopy of naturally occurring substances. XLV. Iboga alkaloids.
The carbon shifts of the Iboga-type alkaloids catharanthine, voacangine, coronaridine, ibogaine, dihydrocatharanthine and epiibogamine were recorded and correlated with the conformation of theExpand
The 13C nuclear magnetic resonance spectra of a series of 40 substituted anisoles have been obtained to investigate the effects of substitution on the aromatic and methoxyl carbon shieldings. ThisExpand