Carbazomycinal and 6-methoxycarbazomycinal as aerial mycelium formation-inhibitory substances of Streptoverticillium species.

  title={Carbazomycinal and 6-methoxycarbazomycinal as aerial mycelium formation-inhibitory substances of Streptoverticillium species.},
  author={S. Kondo and M. Katayama and S. Marumo},
  journal={The Journal of antibiotics},
  volume={39 5},
Chemopreventive activity of Hydroethanolic Murraya koenigii leaves extract (HEMKLE) against chemically induced skin carcinogenesis in mice.
  • Sarvnarinder Kaur, S. Dogra, Shilpa Sadwal, Aniqa Aniqa
  • Medicine, Chemistry
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2020
The chemoprotective response of HEMKLE was evident by inhibition in tumor incidence, mean tumor volume,mean tumor burden, total number of tumors, and tumor size in Group IV (HEMKle + DMBA/TPA) when compared to Group II (DMBA /TPA). Expand
Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest
A previously designed and developed 12‐step total synthesis that includes [1,1′‐biphenyl]‐2‐amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G wasExpand
Regioselective C3 Functionalizations of 9H‐Carbazoles via C(sp2)−H Insertions of RhII Carbenoids
We report the direct regioselective C3-functionalization of 9H-carbazoles through the C(sp2)-H insertion of α-imino rhodium(II) carbenoids generated in situ from 1-sulfonyl-1,2,3-triazoles. A varietyExpand
Synthesis of Carbazole Analogs via Grob Fragmentation of Norbornyl α-Diketones
Abstract A regioselective synthesis of carbazole analogs belonging to both the categories of natural origin, viz., microorganisms and higher plant source is reported. The synthesis of carbazoleExpand
New Methods to Induce and Detect Microbial Secondary Metabolite Production
CHEMISTRY NEW METHODS TO INDUCE AND DETECT MICROBIAL SECONDARY METABOLITE PRODUCTION C. RUTH MCNEES Dissertation under the direction of Professor Brian O. Bachmann Secondary metabolite production byExpand
Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione
The antibacterial activity of Murrayaquinone A and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione, a synthetic carbazoloquinone obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive and Gram-negative bacteria. Expand
In Vitro Activity of Synthesized 6-Chloro-2-methyl-1H-carbazole- 1, 4(9H)-dione against Methicillin-Resistant Staphylococcus aureus
The antimicrobial activity of synthesized 6-chloro-2-methyl-1H-carbazole-1,4(9H)-dione and 6- chloro-3-methyl-1H-carbazole-1,4(9H)-dione were studied against Escherichia coli (MTCC 42), BacillusExpand
Total Synthesis of Carbazomycin G by a Thermal Ring Expansion/Self‐Redox Reaction Cascade
The total synthesis of carbazomycin G (7) has been accomplished in six steps and 26 % overall yield starting from commercially available materials. As an efficient access to the tricyclic skeleton ofExpand
Total Synthesis of Carbazomycin G
A concise total synthesis of carbazomycin G has been completed in five steps. Cerium(IV) ammonium nitrate (CAN)–SiO2-mediated oxidation of 2-methyl-2,3,4,9-tetrahydro-1H- carbazol-1-one afforded aExpand


New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis.
The carbazomycin-producing microorganism, strain H 1051-MY 10, was determined to a strain of Streptoverticillium ehimense and neither of the labeled carbons, [1-14C]tryptophan nor [2,3-13C]propionic acid, was detected in the antibiotic, and a progenitor of the C-2 and C-11 moiety of the antibiotic has not been determined. Expand
New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties.
An unidentified Streptomyces, designated as Strain H 1051-MY 10, was proved to produce viomycin and two new antibiotics, which inhibited the growth of phytophathogenic fungi and further showed weak antibacterial and antiyeast activities. Expand
Pamamycin: a new antibiotic and stimulator of aerial mycelia formation.
Pamamycin is a new antibiotic isolated from Streptomyces alboniger ATCC 12461. The antibiotic is active in vitro against Gram-positive bacteria, Neurospora, and Mycobacteria. The compound also actsExpand
Simultaneous loss of multiple differentiated functions in aerial mycelium-negative isolates of streptomycetes
The lack of any detectable reversion, coupled with the high frequency of curing, supports the idea that a deletion of genetic material, possibly a plasmid, has occurred in Streptomyces alboniger. Expand
Advances in Streptomyces coelicolor genetics.
Effect of A-factor on the growth of asporogenous mutants of Streptomyces griseus, not producing this factor.
A-factor C13H22O4 was shown to be not only the inductor of the biosynthesis of streptomycin in inactive mutants of Streptomyces griseus (Actinomyces streptomycini), but also the potent regulator ofExpand