Carbazole Antibiotics Synthesis in a Streptomyces tendae Bald Mutant, Created by Acriflavine Treatment

@article{Grammel1998CarbazoleAS,
  title={Carbazole Antibiotics Synthesis in a Streptomyces tendae Bald Mutant, Created by Acriflavine Treatment},
  author={H. Grammel and H. Wolf and E. Gilles and F. Huth and H. Laatsch},
  journal={Zeitschrift f{\"u}r Naturforschung C},
  year={1998},
  volume={53},
  pages={325 - 330}
}
  • H. Grammel, H. Wolf, +2 authors H. Laatsch
  • Published 1998
  • Medicine, Biology
  • Zeitschrift für Naturforschung C
  • Abstract Acriflavine treatment on Streptomyces tendae generated a bald mutant (bid-1) with an altered antibiotic pattern. The parental strain produced nikkomycins and juglomycins, whereas the mutant bid-1 was only capable of juglomycin synthesis. The existence of a mutant defective in morphogenesis and in nikkomycin biosynthesis suggests a common regulation of these processes. An interesting finding of this study is that mutant bld-1 produced two carbazole derivatives, hitherto never seen in… CONTINUE READING
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